Macrophage pyroptosis promotes synovial fibrosis through the HMGB1/TGF- ß1 axis: an in vivo and in vitro study.

Wu, Peng; Liao, Taiyang; Ma, Zhenyuan; Wei, Yibao; Yin, Songjiang; Huang, Zhengquan; Mao, Jun

Wu, Peng; Liao, Taiyang; Ma, Zhenyuan; Wei, Yibao; Yin, Songjiang; Huang, Zhengquan; Mao, Jun.

Afiliação

Wu P; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.
Liao T; Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China.
Ma Z; Key Laboratory for Metabolic Diseases in Chinese Medicine, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Wei Y; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.
Yin S; Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China.
Huang Z; Key Laboratory for Metabolic Diseases in Chinese Medicine, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Mao J; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.

In Vitro Cell Dev Biol Anim ; 59(4): 289-299, 2023 Apr.

Article em En | MEDLINE | ID: mdl-37195554

Assuntos

Proteína HMGB1; Ratos; Animais; Fator de Crescimento Transformador beta1; Interleucina-18/metabolismo; Vimentina/metabolismo; Proteína HMGB1/metabolismo; Piroptose; Fibrose; Colágeno Tipo I/genética; Macrófagos/metabolismo

Palavras-chave

Fibrosis; Knee osteoarthritis; Pyroptosis; Synovial fibroblasts; Synovial macrophages; Synovitis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína HMGB1 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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