Mannosylated polydopamine nanoparticles alleviate radiation- induced pulmonary fibrosis by targeting M2 macrophages and inhibiting the TGF-ß1/Smad3 signaling pathway.

Shen, Li; Fu, Shiyan; Chen, Yonglai; Li, Wenrun; Liu, Suiyi; Li, Zhi; Li, Jie; Li, Yong; Ran, Yonghong; Zhang, Jing; Qiao, Lu; Hao, Yuhui

Shen, Li; Fu, Shiyan; Chen, Yonglai; Li, Wenrun; Liu, Suiyi; Li, Zhi; Li, Jie; Li, Yong; Ran, Yonghong; Zhang, Jing; Qiao, Lu; Hao, Yuhui.

Afiliação

Shen L; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.
Fu S; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.
Chen Y; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.
Li W; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.
Liu S; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.
Li Z; Medical Service Training Center, Central Theater Command General Hospital, Wuhan 430070, China.
Li J; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.
Li Y; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.
Ran Y; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.
Zhang J; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.
Qiao L; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China.
Hao Y; College of Preventive Medicine, Army Military Medical University, Chongqing 400038, China. Electronic address: yuhui_hao@126.com.

Colloids Surf B Biointerfaces ; 227: 113353, 2023 Jul.

Article em En | MEDLINE | ID: mdl-37196463

Assuntos

Nanopartículas; Fibrose Pulmonar; Camundongos; Animais; Fibrose Pulmonar/tratamento farmacológico; Fibrose Pulmonar/induzido quimicamente; Fibrose Pulmonar/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Pulmão/metabolismo; Transdução de Sinais; Macrófagos/metabolismo

Palavras-chave

M2 macrophages; Mannosylated polydopamine nanoparticles; Mucus penetration; Radiation-induced pulmonary fibrosis; TGF-ß1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Nanopartículas Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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