High-Quality Sleep Mitigates ABCA7-Related Generalization Deficits in Healthy Older African Americans.
J Alzheimers Dis
; 94(1): 281-290, 2023.
Article
em En
| MEDLINE
| ID: mdl-37212111
ABSTRACT
BACKGROUND:
Both sleep deficiencies and Alzheimer's disease (AD) disproportionately affect older African Americans. Genetic susceptibility to AD further compounds risk for cognitive decline in this population. Aside from APOE É4, ABCA7 rs115550680 is the strongest genetic locus associated with late-onset AD in African Americans. While sleep and ABCA7 rs115550680 independently influence late-life cognitive outcomes, we know too little about the interplay between these two factors on cognitive function.OBJECTIVE:
We investigated the interaction between sleep and ABCA7 rs115550680 on hippocampal-dependent cognitive function in older African Americans.METHODS:
One-hundred fourteen cognitively healthy older African Americans were genotyped for ABCA7 risk (nâ=â57 carriers of risk "G" allele; nâ=â57 non-carriers), responded to lifestyle questionnaires, and completed a cognitive battery. Sleep was assessed via a self-reported rating of sleep quality (poor, average, good). Covariates included age and years of education.RESULTS:
Using ANCOVA, we found that carriers of the risk genotype who reported poor or average sleep quality demonstrated significantly poorer generalization of prior learning-a cognitive marker of AD-compared to their non-risk counterparts. Conversely, there was no genotype-related difference in generalization performance in individuals who reported good sleep quality.CONCLUSION:
These results indicate that sleep quality may be neuroprotective against genetic risk for AD. Future studies employing more rigorous methodology should investigate the mechanistic role of sleep neurophysiology in the pathogenesis and progression of AD associated with ABCA7. There is also need for the continued development of non-invasive sleep interventions tailored to racial groups with specific AD genetic risk profiles.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Sono
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Negro ou Afro-Americano
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Transportadores de Cassetes de Ligação de ATP
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Doença de Alzheimer
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Disfunção Cognitiva
Limite:
Aged
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Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article