Antibacterial activity of paroxetine against Staphylococcus aureus and possible mechanisms of action.
Future Microbiol
; 18: 415-426, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-37213136
ABSTRACT
Aim:
To evaluate the antibacterial activity of paroxetine alone and associated with oxacillin against isolates of methicillin-sensitive and -resistant Staphylococcus aureus. Materials &methods:
The broth microdilution and checkerboard techniques were used, with investigation of possible mechanisms of action through flow cytometry, fluorescence microscopy and molecular docking, in addition to scanning electron microscopy for morphological analysis.Results:
Paroxetine showed a MIC of 64 µg/ml and bactericidal activity, mostly additive interactions in combination with oxacillin, evidence of action on genetic material and membrane, morphological changes in microbial cells and influence on virulence factors.Conclusion:
Paroxetine has antibacterial potential from the perspective of drug repositioning.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
/
Staphylococcus aureus Resistente à Meticilina
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article