Rate of Colectomy Increases Within 12 Months of Sequential Therapy for Ulcerative Colitis.
Am J Gastroenterol
; 118(11): 2080-2083, 2023 11 01.
Article
em En
| MEDLINE
| ID: mdl-37216596
ABSTRACT
INTRODUCTION:
Patients with medically refractory ulcerative colitis who previously would have undergone surgery can now elect for subsequent medical therapy.METHODS:
In a commercially insured population, we evaluated the proportion of patients initiating second-line, third-line, or fourth-line treatment who underwent colectomy in the following 12 months.RESULTS:
Among 3,325 patients with ulcerative colitis, the colectomy rate within 12 months of a switch in therapy increased from 12% with the first switch to 17% and 19% with the second and third switches, respectively ( P < 0.001).DISCUSSION:
Treatment effectiveness declines with successive switching; however, even after initiating fourth-line therapy, most patients remain surgery-free.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colite Ulcerativa
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article