COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.

Zhu, Sai-Ya; Zhou, Wen-Qian; Niu, Yang-Yang; Zheng, Chao; Liu, Xi; Zhang, Ying-Ying; Yu, Chen

Zhu, Sai-Ya; Zhou, Wen-Qian; Niu, Yang-Yang; Zheng, Chao; Liu, Xi; Zhang, Ying-Ying; Yu, Chen.

Afiliação

Zhu SY; Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Zhou WQ; Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Niu YY; Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Zheng C; Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Liu X; Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Zhang YY; Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Yu C; Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. yuchen@tongji.edu.cn.

Acta Pharmacol Sin ; 44(10): 2091-2102, 2023 Oct.

Article em En | MEDLINE | ID: mdl-37217601

Assuntos

Cobre; Nefropatias; Obstrução Ureteral; Animais; Camundongos; Ratos; Linhagem Celular; Cobre/metabolismo; Fibrose; Nefropatias/metabolismo; Mitocôndrias/metabolismo; Obstrução Ureteral/metabolismo; Complexo IV da Cadeia de Transporte de Elétrons/metabolismo

Palavras-chave

COX17; NRK-52E cells; copper; cytochrome c oxidase; mitochondria; renal fibrosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Obstrução Ureteral / Cobre / Nefropatias Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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