Targeting unfolded protein response reverts ER stress and ER Ca<sup>2+</sup> homeostasis in cardiomyocytes expressing the pathogenic variant of Lamin A/C R321X.

Pietrafesa, Giusy; De Zio, Roberta; Scorza, Simona Ida; Armentano, Maria Francesca; Pepe, Martino; Forleo, Cinzia; Procino, Giuseppe; Gerbino, Andrea; Svelto, Maria; Carmosino, Monica

Targeting unfolded protein response reverts ER stress and ER Ca²⁺ homeostasis in cardiomyocytes expressing the pathogenic variant of Lamin A/C R321X.

Pietrafesa, Giusy; De Zio, Roberta; Scorza, Simona Ida; Armentano, Maria Francesca; Pepe, Martino; Forleo, Cinzia; Procino, Giuseppe; Gerbino, Andrea; Svelto, Maria; Carmosino, Monica.

Afiliação

Pietrafesa G; Department of Sciences, University of Basilicata, Potenza, Italy.
De Zio R; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Bari, Italy.
Scorza SI; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Bari, Italy.
Armentano MF; Department of Sciences, University of Basilicata, Potenza, Italy.
Pepe M; Cardiology Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.
Forleo C; Cardiology Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.
Procino G; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Bari, Italy.
Gerbino A; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Bari, Italy.
Svelto M; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Bari, Italy.
Carmosino M; Department of Sciences, University of Basilicata, Potenza, Italy. monica.carmosino@unibas.it.

J Transl Med ; 21(1): 340, 2023 05 22.

Article em En | MEDLINE | ID: mdl-37217929

Assuntos

Lamina Tipo A; Miócitos Cardíacos; Humanos; Apoptose; eIF-2 Quinase/genética; eIF-2 Quinase/metabolismo; Retículo Endoplasmático/metabolismo; Estresse do Retículo Endoplasmático; Guanabenzo/farmacologia; Homeostase; Lamina Tipo A/genética; Lamina Tipo A/metabolismo; Miócitos Cardíacos/metabolismo; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Resposta a Proteínas não Dobradas

Palavras-chave

Cardiomyocytes; Cardiomyopathy; ER stress; Empagliflozin; Guanabenz; Lamin A/C

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miócitos Cardíacos / Lamina Tipo A Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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