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Polycephalums A and B, New Anticoagulant Constituents Isolated from Clinopodium polycephalum.
Tao, Muke; Liu, Yaxuan; Zhou, Xiangmin; Yu, Xinlan; Zhang, Yi; Guo, Li; Meng, Dali.
Afiliação
  • Tao M; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
  • Liu Y; Chongqing Institute for Food and Drug Control, NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances, Chongqing, 401121, P. R. China.
  • Zhou X; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China.
  • Yu X; Chongqing Institute for Food and Drug Control, NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances, Chongqing, 401121, P. R. China.
  • Zhang Y; Xinjiang Institute for Drug Control, Urumqi, 830004, P. R. China.
  • Guo L; Chongqing Institute for Food and Drug Control, NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances, Chongqing, 401121, P. R. China.
  • Meng D; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
Chem Biodivers ; 20(6): e202300448, 2023 Jun.
Article em En | MEDLINE | ID: mdl-37218541
Two previously undescribed compounds (1 and 2) were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses and extensive 2D-homo and heteronuclear NMR data interpretations. Both compounds 1 and 2 could significantly shorten APTT and PT, and their procoagulant effect was comparable to that of positive drugs. At the same time, compound 2 had certain antioxidant activity (IC50 value of 2.25±0.05 µM in ABTS assay).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Lamiaceae País como assunto: Asia Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Lamiaceae País como assunto: Asia Idioma: En Ano de publicação: 2023 Tipo de documento: Article