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Influence of Cirrhosis on 68Ga-FAPI PET/CT in Intrahepatic Tumors.
Peng, Dengsai; Cao, Jianpeng; Guo, Chunmei; He, Jing; Yang, Liping; Zhang, Jinping; Yang, Jian; Feng, Yue; Xu, Tingting; Chen, Yue.
Afiliação
  • Peng D; From the Departments of Nuclear Medicine (D.P., C.G., L.Y., J.Y., Y.F., T.X., Y.C.) and Pathology (J.Z.), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, PR China; Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Med
  • Cao J; From the Departments of Nuclear Medicine (D.P., C.G., L.Y., J.Y., Y.F., T.X., Y.C.) and Pathology (J.Z.), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, PR China; Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Med
  • Guo C; From the Departments of Nuclear Medicine (D.P., C.G., L.Y., J.Y., Y.F., T.X., Y.C.) and Pathology (J.Z.), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, PR China; Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Med
  • He J; From the Departments of Nuclear Medicine (D.P., C.G., L.Y., J.Y., Y.F., T.X., Y.C.) and Pathology (J.Z.), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, PR China; Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Med
  • Yang L; From the Departments of Nuclear Medicine (D.P., C.G., L.Y., J.Y., Y.F., T.X., Y.C.) and Pathology (J.Z.), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, PR China; Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Med
  • Zhang J; From the Departments of Nuclear Medicine (D.P., C.G., L.Y., J.Y., Y.F., T.X., Y.C.) and Pathology (J.Z.), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, PR China; Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Med
  • Yang J; From the Departments of Nuclear Medicine (D.P., C.G., L.Y., J.Y., Y.F., T.X., Y.C.) and Pathology (J.Z.), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, PR China; Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Med
  • Feng Y; From the Departments of Nuclear Medicine (D.P., C.G., L.Y., J.Y., Y.F., T.X., Y.C.) and Pathology (J.Z.), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, PR China; Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Med
  • Xu T; From the Departments of Nuclear Medicine (D.P., C.G., L.Y., J.Y., Y.F., T.X., Y.C.) and Pathology (J.Z.), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, PR China; Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Med
  • Chen Y; From the Departments of Nuclear Medicine (D.P., C.G., L.Y., J.Y., Y.F., T.X., Y.C.) and Pathology (J.Z.), The Affiliated Hospital of Southwest Medical University, No. 25 Taiping St, Jiangyang District, Luzhou 646000, PR China; Department of Nuclear Medicine, Second Affiliated Hospital of Chengdu Med
Radiology ; 307(5): e222448, 2023 06.
Article em En | MEDLINE | ID: mdl-37219440
Background Gallium 68 (68Ga)-labeled fibroblast activation protein inhibitor (FAPI) is of great diagnostic value for intrahepatic tumors. However, cirrhosis may lead to increased 68Ga-FAPI uptake in background liver, affecting the diagnostic ability of 68Ga-FAPI. Purpose To assess the effect of cirrhosis on liver parenchyma and intrahepatic tumor uptake of 68Ga-FAPI and to compare the ability of 68Ga-FAPI and fluorine 18 (18F)-labeled fluorodeoxyglucose (FDG) PET/CT to depict intrahepatic tumors in patients with cirrhosis. Materials and Methods In this secondary analysis of a prospective trial, patients who underwent both 68Ga-FAPI and 18F-FDG PET/CT and those who underwent only 68Ga-FAPI PET/CT between August 2020 and May 2022 were considered for inclusion in the cirrhotic or noncirrhotic group, respectively. Patients with cirrhosis were chosen via a comprehensive assessment of imaging and clinical data, and patients without cirrhosis were randomly selected. 68Ga-FAPI and 18F-FDG PET/CT data were measured by two radiologists. Between-groups and within-group data were tested with the Mann-Whitney U test and the Wilcoxon signed-rank test, respectively. Results A total of 39 patients with cirrhosis (median age, 58 years [IQR, 50-68]; 29 male; 24 intrahepatic tumors) and 48 patients without cirrhosis (median age, 59 years [IQR, 51-67]; 30 male; 23 intrahepatic tumors) were evaluated. In patients without intrahepatic tumors, the liver 68Ga-FAPI average standardized uptake value (SUVavg) was higher in the cirrhotic group than in the noncirrhotic group (median SUVavg, 1.42 [IQR, 0.55-2.85] vs 0.45 [IQR, 0.41-0.72]; P = .002). However, no difference was observed in the diagnosis of intrahepatic tumor sensitivity (98% vs 93%, respectively). When compared with 18F-FDG, the sensitivity of 68Ga-FAPI PET/CT in the detection of intrahepatic tumors in patients with cirrhosis (41% vs 98%, respectively) and maximum standardized uptake value of tumors (median SUVmax, 2.60 [IQR, 2.14-4.49] vs 6.68 [IQR, 4.65-10.08]; P < .001) were higher. Conclusion The sensitivity of 68Ga-FAPI in the diagnosis of intrahepatic tumors was not affected by cirrhosis, and diagnostic accuracy of 68Ga-FAPI was higher than that of 18F-FDG in patients with cirrhosis. © RSNA, 2023 Supplemental material is available for this article.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Neoplasias Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Neoplasias Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article