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The initial age-associated decline in early T-cell progenitors reflects fewer pre-thymic progenitors and altered signals in the bone marrow and thymus microenvironments.
Srinivasan, Jayashree; Vasudev, Anusha; Shasha, Carolyn; Selden, Hilary J; Perez, Encarnacion; LaFleur, Bonnie; Sinari, Shripad A; Krueger, Andreas; Richie, Ellen R; Ehrlich, Lauren I R.
Afiliação
  • Srinivasan J; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States.
  • Vasudev A; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
  • Shasha C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States.
  • Selden HJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States.
  • Perez E; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
  • LaFleur B; Center for Biomedical Informatics and Statistics, The University of Arizona, Tucson, Arizona, United States.
  • Sinari SA; Center for Biomedical Informatics and Statistics, The University of Arizona, Tucson, Arizona, United States.
  • Krueger A; Molecular Immunology, Justus-Liebig-University Giessen, Giessen, Germany.
  • Richie ER; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
  • Ehrlich LIR; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States.
Aging Cell ; 22(8): e13870, 2023 08.
Article em En | MEDLINE | ID: mdl-37221658
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medula Óssea / Linfócitos T Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medula Óssea / Linfócitos T Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article