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A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses.
Cohen, Kristen W; De Rosa, Stephen C; Fulp, William J; deCamp, Allan C; Fiore-Gartland, Andrew; Mahoney, Celia R; Furth, Sarah; Donahue, Josh; Whaley, Rachael E; Ballweber-Fleming, Lamar; Seese, Aaron; Schwedhelm, Katharine; Geraghty, Daniel; Finak, Greg; Menis, Sergey; Leggat, David J; Rahaman, Farhad; Lombardo, Angela; Borate, Bhavesh R; Philiponis, Vincent; Maenza, Janine; Diemert, David; Kolokythas, Orpheus; Khati, Nadia; Bethony, Jeffrey; Hyrien, Ollivier; Laufer, Dagna S; Koup, Richard A; McDermott, Adrian B; Schief, William R; McElrath, M Juliana.
Afiliação
  • Cohen KW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • De Rosa SC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Fulp WJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • deCamp AC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Fiore-Gartland A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Mahoney CR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Furth S; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Donahue J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Whaley RE; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Ballweber-Fleming L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Seese A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Schwedhelm K; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Geraghty D; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Finak G; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Menis S; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92307, USA.
  • Leggat DJ; Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92307, USA.
  • Rahaman F; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92307, USA.
  • Lombardo A; Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA.
  • Borate BR; IAVI, 125 Broad Street, 9th Floor, New York, NY 10004, USA.
  • Philiponis V; IAVI, 125 Broad Street, 9th Floor, New York, NY 10004, USA.
  • Maenza J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Diemert D; IAVI, 125 Broad Street, 9th Floor, New York, NY 10004, USA.
  • Kolokythas O; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Khati N; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
  • Bethony J; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, Washington DC, 20052, USA.
  • Hyrien O; Department of Medicine, School of Medicine and Health Sciences, George Washington University, Washington DC 20052, USA.
  • Laufer DS; Department of Radiology, University of Washington, Seattle, WA 98195, USA.
  • Koup RA; Department of Radiology, School of Medicine and Health Sciences, George Washington University, Washington DC 20052, USA.
  • McDermott AB; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, Washington DC, 20052, USA.
  • Schief WR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • McElrath MJ; IAVI, 125 Broad Street, 9th Floor, New York, NY 10004, USA.
Sci Transl Med ; 15(697): eadf3309, 2023 05 24.
Article em En | MEDLINE | ID: mdl-37224227
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Vacinas contra a AIDS Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Vacinas contra a AIDS Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article