A Concise Synthetic Approach to Highly Reactive Click-to-Release Trans-Cyclooctene Linkers.

Liu, Bing; Ten Hoeve, Wolter; Versteegen, Ron M; Rossin, Raffaella; Kleijn, Laurens H J; Robillard, Marc S

Liu, Bing; Ten Hoeve, Wolter; Versteegen, Ron M; Rossin, Raffaella; Kleijn, Laurens H J; Robillard, Marc S.

Afiliação

Liu B; Tagworks Pharmaceuticals, Toernooiveld 1, 6525âED, Nijmegen, The Netherlands.
Ten Hoeve W; Symeres, Kadijk 3, 9747âAT, Groningen, The Netherlands.
Versteegen RM; SyMO-Chem, Den Dolech 2, 5612âAZ, Eindhoven, The Netherlands.
Rossin R; Tagworks Pharmaceuticals, Toernooiveld 1, 6525âED, Nijmegen, The Netherlands.
Kleijn LHJ; Tagworks Pharmaceuticals, Toernooiveld 1, 6525âED, Nijmegen, The Netherlands.
Robillard MS; Tagworks Pharmaceuticals, Toernooiveld 1, 6525âED, Nijmegen, The Netherlands.

Chemistry ; 29(45): e202300755, 2023 Aug 10.

Article em En | MEDLINE | ID: mdl-37224460

Assuntos

Ciclo-Octanos; Sistemas de Liberação de Medicamentos; Animais; Camundongos; Ciclo-Octanos/química

Palavras-chave

cleavable linkers; click chemistry; iodolactonization; pyridazine elimination; trans-cyclooctene

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Ciclo-Octanos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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