Impact of Catheter Ablation on Cognitive Function in Atrial Fibrillation: A Randomized Control Trial.
JACC Clin Electrophysiol
; 9(7 Pt 2): 1024-1034, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-37227345
ABSTRACT
BACKGROUND:
Early postoperative cognitive dysfunction (POCD) has been reported following atrial fibrillation (AF) ablation. However, whether POCD is persistent long-term is unknown.OBJECTIVES:
The purpose of this study was to determine if AF catheter ablation is associated with persistent cognitive dysfunction at 12-month follow-up.METHODS:
This is a prospective study of 100 patients with symptomatic AF who failed at least 1 antiarrhythmic drug randomized to either ongoing medical therapy or AF catheter ablation and followed up for 12 months. Changes in cognitive performance were assessed using 6 cognitive tests administered at baseline and during follow-up (3, 6, and 12 months).RESULTS:
A total of 96 participants completed the study protocol. Mean age was 59 ± 12 years (32% women, 46% with persistent AF). The prevalence of new cognitive dysfunction in the ablation arm compared with the medical arm was as follows at 3 months 14% vs 2%; P = 0.03; at 6 months 4% vs 2%; P = NS; and at 12 months 0% vs 2%; P = NS. Ablation time was an independent predictor of POCD (P = 0.03). A significant improvement in cognitive scores was seen in 14% of the ablation arm patients at 12 months compared with no patients in the medical arm (P = 0.007).CONCLUSIONS:
POCD was observed following AF ablation. However, this was transient with complete recovery at 12-month follow-up.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Atrial
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Ablação por Cateter
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Disfunção Cognitiva
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Guideline
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article