Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases.
J Transl Med
; 21(1): 347, 2023 05 25.
Article
em En
| MEDLINE
| ID: mdl-37231493
ABSTRACT
Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in the onset and development of CVD. Nowadays, mitochondrial transplantation, an alternative treatment aimed at increasing mitochondrial number and improving mitochondrial function, has been emerged with great therapeutic potential. Substantial evidence indicates that mitochondrial transplantation improves cardiac function and outcomes in patients with CVD. Therefore, mitochondrial transplantation has profound implications in the prevention and treatment of CVD. Here, we review the mitochondrial abnormalities that occur in CVD and summarize the therapeutic strategies of mitochondrial transplantation for CVD.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article