Synthesis of fused tetramate-oxazolidine and -imidazolidine derivatives and their antibacterial activity.
Org Biomol Chem
; 21(23): 4801-4809, 2023 06 14.
Article
em En
| MEDLINE
| ID: mdl-37232452
ABSTRACT
A chemoselective route which provides direct access to bicyclic tetramates, making use of Dieckmann cyclisation of functionalised oxazolidines and imidazolidines derived from an aminomalonate, is reported; calculations suggest that the observed chemoselectivity is kinetically controlled and leads to the thermodynamically most stable product. Some compounds in the library showed modest antibacterial activity against Gram-positive bacteria, and this activity is maximal in a well-defined region of chemical space (554 < Mw < 722 g mol-1; 5.78 < cLogP < 7.16; 788 < MSA < 972 Å2; 10.3 < rel. PSA < 19.08).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imidazolidinas
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article