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Lipidation of a bioactive cyclotide-based CXCR4 antagonist greatly improves its pharmacokinetic profile in vivo.
Chaudhuri, Dipankar; Lu, Tiangong; Jacob, Binu; Abraham, Sojan; Shankar, Premlata; Poss, Michael A; Neamati, Nouri; Camarero, Julio A.
Afiliação
  • Chaudhuri D; Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  • Lu T; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-2800, USA.
  • Jacob B; Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  • Abraham S; Department of Biomedical Sciences, Center of Excellence in Infectious Disease, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79430, USA.
  • Shankar P; Department of Biomedical Sciences, Center of Excellence in Infectious Disease, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79430, USA.
  • Poss MA; Bristol Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Neamati N; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-2800, USA.
  • Camarero JA; Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA9033, USA. Electronic address: j
J Control Release ; 359: 26-32, 2023 07.
Article em En | MEDLINE | ID: mdl-37236320

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Ciclotídeos / Neoplasias Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Ciclotídeos / Neoplasias Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article