Advances in Oocyte Maturation In Vivo and In Vitro in Mammals.
Int J Mol Sci
; 24(10)2023 May 21.
Article
em En
| MEDLINE
| ID: mdl-37240406
ABSTRACT
The quality and maturation of an oocyte not only play decisive roles in fertilization and embryo success, but also have long-term impacts on the later growth and development of the fetus. Female fertility declines with age, reflecting a decline in oocyte quantity. However, the meiosis of oocytes involves a complex and orderly regulatory process whose mechanisms have not yet been fully elucidated. This review therefore mainly focuses on the regulation mechanism of oocyte maturation, including folliculogenesis, oogenesis, and the interactions between granulosa cells and oocytes, plus in vitro technology and nuclear/cytoplasm maturation in oocytes. Additionally, we have reviewed advances made in the single-cell mRNA sequencing technology related to oocyte maturation in order to improve our understanding of the mechanism of oocyte maturation and to provide a theoretical basis for subsequent research into oocyte maturation.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oócitos
/
Oogênese
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article