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HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues.
Lockbaum, Gordon J; Rusere, Linah N; Henes, Mina; Kosovrasti, Klajdi; Rao, Desaboini Nageswara; Spielvogel, Ean; Lee, Sook-Kyung; Nalivaika, Ellen A; Swanstrom, Ronald; Yilmaz, Nese Kurt; Schiffer, Celia A; Ali, Akbar.
Afiliação
  • Lockbaum GJ; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, United States.
  • Rusere LN; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, United States.
  • Henes M; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, United States.
  • Kosovrasti K; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, United States.
  • Rao DN; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, United States.
  • Spielvogel E; Department of Biochemistry and Biophysics, And the UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.
  • Lee SK; Department of Biochemistry and Biophysics, And the UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.
  • Nalivaika EA; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, United States.
  • Swanstrom R; Department of Biochemistry and Biophysics, And the UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.
  • Yilmaz NK; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, United States.
  • Schiffer CA; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, United States. Electronic address: Celia.Schiffer@umassmed.edu.
  • Ali A; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, United States. Electronic address: Akbar.Ali@umassmed.edu.
Eur J Med Chem ; 257: 115501, 2023 Sep 05.
Article em En | MEDLINE | ID: mdl-37244161
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: HIV-1 / Inibidores da Protease de HIV Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: HIV-1 / Inibidores da Protease de HIV Idioma: En Ano de publicação: 2023 Tipo de documento: Article