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RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights.
Rhodes, Steven D; McCormick, Frank; Cagan, Ross L; Bakker, Annette; Staedtke, Verena; Ly, Ina; Steensma, Matthew R; Lee, Sang Y; Romo, Carlos G; Blakeley, Jaishri O; Sarin, Kavita Y.
Afiliação
  • Rhodes SD; Division of Hematology-Oncology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA; Herman B Wells Center for Pediatric Research, Indiana Univers
  • McCormick F; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA; Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Cagan RL; School of Cancer Sciences, University of Glasgow, Glasgow, Scotland.
  • Bakker A; Children's Tumor Foundation, New York, New York, USA.
  • Staedtke V; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Ly I; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Steensma MR; Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, USA; Helen DeVos Children's Hospital, Spectrum Health System, Grand Rapids, Michigan, USA; College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA.
  • Lee SY; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Romo CG; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Blakeley JO; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Sarin KY; Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA. Electronic address: ksarin@stanford.edu.
J Invest Dermatol ; 143(8): 1358-1368, 2023 08.
Article em En | MEDLINE | ID: mdl-37245145
ABSTRACT
Cutaneous neurofibromas (cNFs) are the most common tumor in people with the rasopathy neurofibromatosis type 1. They number in hundreds or even thousands throughout the body, and currently, there are no effective interventions to prevent or treat these skin tumors. To facilitate the identification of novel and effective therapies, essential studies including a more refined understanding of cNF biology and the role of RAS signaling and downstream effector pathways responsible for cNF initiation, growth, and maintenance are needed. This review highlights the current state of knowledge of RAS signaling in cNF pathogenesis and therapeutic development for cNF treatment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Neurofibromatose 1 / Neurofibroma Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Neurofibromatose 1 / Neurofibroma Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article