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Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease.
Matsui, Hideaki; Ito, Shinji; Matsui, Hideki; Ito, Junko; Gabdulkhaev, Ramil; Hirose, Mika; Yamanaka, Tomoyuki; Koyama, Akihide; Kato, Taisuke; Tanaka, Maiko; Uemura, Norihito; Matsui, Noriko; Hirokawa, Sachiko; Yoshihama, Maki; Shimozawa, Aki; Kubo, Shin-Ichiro; Iwasaki, Kenji; Hasegawa, Masato; Takahashi, Ryosuke; Hirai, Keisuke; Kakita, Akiyoshi; Onodera, Osamu.
Afiliação
  • Matsui H; Department of Neuroscience of Disease, Center for Transdisciplinary Research, Niigata University, Niigata 951-8585, Japan.
  • Ito S; Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
  • Matsui H; Medical Research Support Center, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
  • Ito J; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa 251-8555, Japan.
  • Gabdulkhaev R; Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
  • Hirose M; Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
  • Yamanaka T; Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
  • Koyama A; Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
  • Kato T; Department of Legal Medicine, Niigata University Graduate School of Medical and Dental Science, Niigata 951-8585, Japan.
  • Tanaka M; Department of System Pathology for Neurological Disorders, Brain Science Branch, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
  • Uemura N; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa 251-8555, Japan.
  • Matsui N; Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
  • Hirokawa S; Department of Neuroscience of Disease, Center for Transdisciplinary Research, Niigata University, Niigata 951-8585, Japan.
  • Yoshihama M; Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
  • Shimozawa A; Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
  • Kubo SI; Frontier Science Research Center, University of Miyazaki, Miyazaki 889-1692, Japan.
  • Iwasaki K; Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
  • Hasegawa M; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa 251-8555, Japan.
  • Takahashi R; Department of Neurology, Parkinson's Disease Center, Eisei Hospital, Tokyo 193-0942, Japan.
  • Hirai K; Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
  • Kakita A; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305-8577, Japan.
  • Onodera O; Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Proc Natl Acad Sci U S A ; 120(23): e2214652120, 2023 06 06.
Article em En | MEDLINE | ID: mdl-37252975
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article