A Potential Nontraditional Approach To Combat <i>tmexCD1-toprJ1-</i>Mediated Tigecycline Resistance: Melatonin as a Synergistic Adjuvant of Tigecycline.

Wang, Xiaoming; Liu, Ting; Lv, Xi; Sun, Naiyan; Li, Fan; Luo, Lei; Zhuge, Xiangkai; Huang, Jinhu; Wang, Liping

A Potential Nontraditional Approach To Combat tmexCD1-toprJ1-Mediated Tigecycline Resistance: Melatonin as a Synergistic Adjuvant of Tigecycline.

Wang, Xiaoming; Liu, Ting; Lv, Xi; Sun, Naiyan; Li, Fan; Luo, Lei; Zhuge, Xiangkai; Huang, Jinhu; Wang, Liping.

Afiliação

Wang X; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Liu T; Risk Assessment Center of Veterinary Drug Residue and Antimicrobial Resistance, Nanjing Agricultural University, Nanjing, China.
Lv X; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Sun N; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Li F; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Luo L; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Zhuge X; College of Pharmaceutical Sciences, Southwest University, Chongqing, China.
Huang J; Department of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, China.
Wang L; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

Antimicrob Agents Chemother ; 67(7): e0004723, 2023 07 18.

Article em En | MEDLINE | ID: mdl-37289048

Assuntos

Infecções por Klebsiella; Melatonina; Animais; Camundongos; Tigeciclina/farmacologia; Melatonina/farmacologia; Melatonina/metabolismo; Minociclina/farmacologia; Infecções por Klebsiella/tratamento farmacológico; Infecções por Klebsiella/microbiologia; Farmacorresistência Bacteriana/genética; Proteínas de Membrana Transportadoras/genética; Antibacterianos/uso terapêutico; Adjuvantes Imunológicos; Adjuvantes Farmacêuticos; Testes de Sensibilidade Microbiana; Klebsiella pneumoniae/genética; Klebsiella pneumoniae/metabolismo

Palavras-chave

melatonin/tigecycline combination; melatonin/tigecycline hybrid; synergistic effect; tigecycline resistance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Klebsiella / Melatonina Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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