Isobavachalcone inhibits RANKL-induced osteoclastogenesis via miR-193-3p/NF-&#954;B/NFATc1 signaling pathway in BMMs cells.

Liu, Xin; Xu, Xiaosa; Li, Jinping; Shi, Liying; Zeng, Ying; Tang, Siyuan; Liu, Wei; Jia, Lujuan; Li, Yuhong; Zhang, Jie

Isobavachalcone inhibits RANKL-induced osteoclastogenesis via miR-193-3p/NF-κB/NFATc1 signaling pathway in BMMs cells.

Liu, Xin; Xu, Xiaosa; Li, Jinping; Shi, Liying; Zeng, Ying; Tang, Siyuan; Liu, Wei; Jia, Lujuan; Li, Yuhong; Zhang, Jie.

Afiliação

Liu X; Department of Pharmachemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Chang Sha, Hunan, China.
Xu X; Department of Pharmachemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Chang Sha, Hunan, China.
Li J; Department of Pharmachemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Chang Sha, Hunan, China.
Shi L; Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Chang Sha, Hunan, China.
Zeng Y; Department of Pharmachemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Chang Sha, Hunan, China.
Tang S; Department of Cardiovascular Medicine, The First Hospital of Hunan University of Traditional Chinese Medicine, Chang Sha, Hunan, China.
Liu W; Department of Community Nursing, Central South University, Changsha, Hunan, China.
Jia L; Department of Community Nursing, Central South University, Changsha, Hunan, China.
Li Y; Department of Pharmachemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Chang Sha, Hunan, China.
Zhang J; Department of Pharmachemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Chang Sha, Hunan, China.

Biosci Biotechnol Biochem ; 87(9): 960-971, 2023 Aug 23.

Article em En | MEDLINE | ID: mdl-37291698

Assuntos

Reabsorção Óssea; MicroRNAs; Osteoporose; Humanos; NF-kappa B/metabolismo; Osteogênese; Ligante RANK/farmacologia; Ligante RANK/metabolismo; Transdução de Sinais; Osteoclastos; Reabsorção Óssea/tratamento farmacológico; Reabsorção Óssea/genética; Reabsorção Óssea/metabolismo; Osteoporose/metabolismo; MicroRNAs/genética; MicroRNAs/metabolismo; Diferenciação Celular; Fatores de Transcrição NFATC/metabolismo

Palavras-chave

NF-κB; RANKL; isobavachalcone; miR-193-3p; osteoclast

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoporose / Reabsorção Óssea / MicroRNAs Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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