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Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma metastases.
Chatziioannou, Eftychia; Roßner, Jana; Aung, Thazin New; Rimm, David L; Niessner, Heike; Keim, Ulrike; Serna-Higuita, Lina Maria; Bonzheim, Irina; Kuhn Cuellar, Luis; Westphal, Dana; Steininger, Julian; Meier, Friedegund; Pop, Oltin Tiberiu; Forchhammer, Stephan; Flatz, Lukas; Eigentler, Thomas; Garbe, Claus; Röcken, Martin; Amaral, Teresa; Sinnberg, Tobias.
Afiliação
  • Chatziioannou E; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Tübingen, Germany.
  • Roßner J; Department of Dermatology, University of Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany.
  • Aung TN; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
  • Rimm DL; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
  • Niessner H; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Tübingen, Germany.
  • Keim U; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany.
  • Serna-Higuita LM; Department of Clinical Epidemiology and Applied Biostatistics, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
  • Bonzheim I; Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany.
  • Kuhn Cuellar L; Quantitative Biology Center (QBiC), University of Tübingen, Tübingen, Germany.
  • Westphal D; Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Skin Cancer Center at the University Cancer Center and National Center for Tumor Diseases, Technical University Dresden, 01307 Dresden, Germany.
  • Steininger J; Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Skin Cancer Center at the University Cancer Center and National Center for Tumor Diseases, Technical University Dresden, 01307 Dresden, Germany.
  • Meier F; Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Skin Cancer Center at the University Cancer Center and National Center for Tumor Diseases, Technical University Dresden, 01307 Dresden, Germany.
  • Pop OT; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Forchhammer S; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany.
  • Flatz L; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Eigentler T; Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
  • Garbe C; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany.
  • Röcken M; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Tübingen, Germany.
  • Amaral T; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Tübingen, Germany.
  • Sinnberg T; Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Tübingen, Germany; Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin B
EBioMedicine ; 93: 104644, 2023 Jul.
Article em En | MEDLINE | ID: mdl-37295047
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Aprendizado Profundo / Melanoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Aprendizado Profundo / Melanoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article