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Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignancies.
Manni, Simona; Del Bufalo, Francesca; Merli, Pietro; Silvestris, Domenico Alessandro; Guercio, Marika; Caruso, Simona; Reddel, Sofia; Iaffaldano, Laura; Pezzella, Michele; Di Cecca, Stefano; Sinibaldi, Matilde; Ottaviani, Alessio; Quadraccia, Maria Cecilia; Aurigemma, Mariasole; Sarcinelli, Andrea; Ciccone, Roselia; Abbaszadeh, Zeinab; Ceccarelli, Manuela; De Vito, Rita; Lodi, Maria Chiara; Cefalo, Maria Giuseppina; Mastronuzzi, Angela; De Angelis, Biagio; Locatelli, Franco; Quintarelli, Concetta.
Afiliação
  • Manni S; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Del Bufalo F; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Merli P; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Silvestris DA; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Guercio M; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Caruso S; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Reddel S; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Iaffaldano L; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Pezzella M; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Di Cecca S; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Sinibaldi M; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Ottaviani A; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Quadraccia MC; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Aurigemma M; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Sarcinelli A; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Ciccone R; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Abbaszadeh Z; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Ceccarelli M; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • De Vito R; Department of Pathological Anatomy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Lodi MC; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Cefalo MG; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • Mastronuzzi A; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
  • De Angelis B; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy. biagio.deangelis@opbg.net.
  • Locatelli F; Department of Haematology-Oncology and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, Rome, Italy. franco.locatelli@opbg.net.
  • Quintarelli C; Department of Pediatrics, Catholic University of the Sacred Heart, Rome, Italy. franco.locatelli@opbg.net.
Nat Commun ; 14(1): 3423, 2023 06 09.
Article em En | MEDLINE | ID: mdl-37296093
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Antígenos Quiméricos / Neoplasias Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Antígenos Quiméricos / Neoplasias Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article