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Circulating Vitamin D Level and Its Impact on Mortality and Recurrence in Stage III Colorectal Cancer Patients: A Systematic Review and Meta-Analysis.
Ottaiano, Alessandro; Facchini, Sergio; Santorsola, Mariachiara; Nasti, Guglielmo; Facchini, Gaetano; Montella, Liliana; Maurea, Nicola; Cascella, Marco; Iervolino, Domenico; Facchini, Bianca Arianna; Montopoli, Monica; Consolo, Pierluigi; Quagliariello, Vincenzo; Rinaldi, Luca; Berretta, Massimiliano.
Afiliação
  • Ottaiano A; Istituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", 80131 Naples, Italy.
  • Facchini S; Division of Medical Oncology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
  • Santorsola M; Istituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", 80131 Naples, Italy.
  • Nasti G; Istituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", 80131 Naples, Italy.
  • Facchini G; Oncology Complex Unit, "S. Maria delle Grazie" Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
  • Montella L; Oncology Complex Unit, "S. Maria delle Grazie" Hospital, ASL NA2 NORD, 80078 Pozzuoli, Italy.
  • Maurea N; Division of Cardiology, IRCCS "G. Pascale", 80131 Naples, Italy.
  • Cascella M; Istituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", 80131 Naples, Italy.
  • Iervolino D; Istituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", 80131 Naples, Italy.
  • Facchini BA; Division of Medical Oncology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
  • Montopoli M; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35122 Padova, Italy.
  • Consolo P; Unit of Digestive Endoscopy, University of Messina, Hospital "G. Martino", 98121 Messina, Italy.
  • Quagliariello V; Division of Cardiology, IRCCS "G. Pascale", 80131 Naples, Italy.
  • Rinaldi L; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
  • Berretta M; Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.
Cancers (Basel) ; 15(11)2023 May 31.
Article em En | MEDLINE | ID: mdl-37296974
BACKGROUND: Vitamin D (VD) has been implicated in several diseases, including colorectal cancer (CRC). This study aimed to determine whether there is an association between VD levels and time-to-outcome in stage III CRC patients through a systematic review and meta-analysis. METHODS: The study adhered to the PRISMA 2020 statement. Articles were searched in PubMed/MEDLINE and Scopus/ELSEVIER. Four articles were selected, with the primary objective of providing a pooled estimate of the risk of death specifically in stage III CRC patients based on pre-operative VD levels. Study heterogeneity and publication bias were analyzed using Tau2 statistics and funnel plots. RESULTS: The selected studies showed significant heterogeneity regarding time-to-outcome, technical assessments, and serum VD concentration measures. The pooled analysis of 2628 and 2024 patients revealed a 38% and 13% increase in the risk of death (HR: 1.38, 95% CI: 0.71-2.71) and recurrence (HR: 1.13; 95% CI: 0.84-1.53), respectively, for random-effects models among patients with lower levels of VD. CONCLUSIONS: Our findings suggest that a low concentration of VD has a significant negative impact on time-to-outcome in stage III CRC.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Systematic_reviews Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Systematic_reviews Idioma: En Ano de publicação: 2023 Tipo de documento: Article