Peptide-Based Nanoparticles for Systemic Extrahepatic Delivery of Therapeutic Nucleotides.
Int J Mol Sci
; 24(11)2023 May 29.
Article
em En
| MEDLINE
| ID: mdl-37298407
ABSTRACT
Peptide-based nanoparticles (PBN) for nucleotide complexation and targeting of extrahepatic diseases are gaining recognition as potent pharmaceutical vehicles for fine-tuned control of protein production (up- and/or down-regulation) and for gene delivery. Herein, we review the principles and mechanisms underpinning self-assembled formation of PBN, cellular uptake, endosomal release, and delivery to extrahepatic disease sites after systemic administration. Selected examples of PBN that have demonstrated recent proof of concept in disease models in vivo are summarized to offer the reader a comparative view of the field and the possibilities for clinical application.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Nanopartículas
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article