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Antimicrobial activity and wound healing effect of a novel natural ointment: an in vitro and in vivo study.
Khodabakhshi, Darioush; Vaseghi, Golnaz; Mirzaee, Arezoo; Eskandarinia, Asghar; Kharazi, Anousheh Zargar.
Afiliação
  • Khodabakhshi D; Department of Biomaterials, Tissue Engineering, and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Hezarjreeb St., 8174673461 Isfahan, Iran.
  • Vaseghi G; Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Hezarjreeb St., 8174673461, Isfahan, Iran.
  • Mirzaee A; Department of Bacteriology and Virology, School of Medicine, Isfahan University of Medical Sciences, Hezarjreeb St., 8174673461, Isfahan, Iran.
  • Eskandarinia A; Department of Biomaterials, Tissue Engineering, and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Hezarjreeb St., 8174673461 Isfahan, Iran.
  • Kharazi AZ; Department of Biomaterials, Tissue Engineering, and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Hezarjreeb St., 8174673461 Isfahan, Iran.
J Wound Care ; 32(Sup6): S18-S26, 2023 Jun 01.
Article em En | MEDLINE | ID: mdl-37300867
Infection and pathological disorders, such as cellular disorders, ischaemia, neuropathy and angiogenesis, are considered the most critical factors which cause a delay in the wound healing process in patients with diabetes. This study aimed to investigate the effect of an ointment based on ostrich oil containing honey, beeswax, and ethanolic extracts of Nigella sativa, propolis and Cassia angustifolia on the wound healing process of diabetic rats. Gas chromatography/mass spectrometry analysis showed caffeic acid and pinostrobin chalcone molecules present in propolis, giving antibacterial and antifungal properties to the compound. The antibacterial assessment showed the ointment had remarkable antibacterial activity against Staphylococcus aureus (8.6±0.28mm), Escherichia coli (9.4±0.31mm), Acinetobacter baumannii (7.2±0.23mm) and Pseudomonas aeruginosa (13.9±0.42mm). In vivo results showed the ointment significantly accelerated wound healing and increased collagen deposition compared with the control (p<0.05). Histopathology evaluation also showed hair follicles, sebaceous glands and vessels in the group that used the ointment. These results proved successful and diabetic wound healing was rapid. Therefore, it could be concluded that the fabricated ointment could be a suitable candidate for wound healing.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Própole / Diabetes Mellitus Experimental Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Própole / Diabetes Mellitus Experimental Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article