Unsaturated fatty acids uniquely alter aggregation rate of &#945;-synuclein and insulin and change the secondary structure and toxicity of amyloid aggregates formed in their presence.

Matveyenka, Mikhail; Zhaliazka, Kiryl; Kurouski, Dmitry

Unsaturated fatty acids uniquely alter aggregation rate of α-synuclein and insulin and change the secondary structure and toxicity of amyloid aggregates formed in their presence.

Matveyenka, Mikhail; Zhaliazka, Kiryl; Kurouski, Dmitry.

Afiliação

Matveyenka M; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.
Zhaliazka K; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.
Kurouski D; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.

FASEB J ; 37(7): e22972, 2023 07.

Article em En | MEDLINE | ID: mdl-37302013

Assuntos

Ácidos Graxos Ômega-3; Doença de Parkinson; Humanos; alfa-Sinucleína/metabolismo; Insulina; Amiloide/toxicidade; Amiloide/química; Ácidos Graxos Insaturados; Proteínas Amiloidogênicas; Ácidos Araquidônicos

Palavras-chave

AFM-IR; LDH; ROS; alpha-synuclein; arachidonic acid; docosahexaenoic acid; insulin; unsaturated farry acids

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Ácidos Graxos Ômega-3 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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