Harnessing Human Pluripotent Stem Cell-Derived Pancreatic In Vitro Models for High-Throughput Toxicity Testing and Diabetes Drug Discovery.

Ching, Carmen; Iich, Elhadi; Teo, Adrian Kee Keong

Ching, Carmen; Iich, Elhadi; Teo, Adrian Kee Keong.

Afiliação

Ching C; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Iich E; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Teo AKK; Precision Medicine Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Handb Exp Pharmacol ; 281: 301-332, 2023.

Article em En | MEDLINE | ID: mdl-37306817

Assuntos

Diabetes Mellitus Tipo 1; Células Secretoras de Insulina; Células-Tronco Pluripotentes; Humanos; Insulina/metabolismo; Células Secretoras de Insulina/metabolismo; Diabetes Mellitus Tipo 1/metabolismo; Diabetes Mellitus Tipo 1/terapia; Descoberta de Drogas; Diferenciação Celular

Palavras-chave

Diabetes; Drug screening; High throughput; Human; Islet; Pancreas; Stem cells; Toxicity; iPS; ß-cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes / Diabetes Mellitus Tipo 1 / Células Secretoras de Insulina Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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