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Differentiation-Promoting Effects of Okeaniamides A and B from an Okeania sp. Marine Cyanobacterium on Preadipocytes.
Ozaki, Kaori; Asato, Yuka; Natsume, Noriyuki; Tojo, Shunya; Sumimoto, Shimpei; Iwasaki, Arihiro; Suenaga, Kiyotake; Teruya, Toshiaki.
Afiliação
  • Ozaki K; Graduate School of Engineering and Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
  • Asato Y; Graduate School of Engineering and Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
  • Natsume N; Graduate School of Engineering and Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
  • Tojo S; Graduate School of Engineering and Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
  • Sumimoto S; Department of Material and Life Chemistry, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
  • Iwasaki A; Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
  • Suenaga K; Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
  • Teruya T; Graduate School of Engineering and Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
J Nat Prod ; 86(6): 1564-1570, 2023 06 23.
Article em En | MEDLINE | ID: mdl-37307100
ABSTRACT
The linear lipopeptides okeaniamide A (1) and okeaniamide B (2) were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were elucidated based on a combination of chemical degradations, Marfey's analysis, and derivatization reactions. Okeaniamide A (1) and okeaniamide B (2) dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cianobactérias / Biologia Marinha Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cianobactérias / Biologia Marinha Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article