An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells.
J Mater Chem B
; 11(26): 6053-6059, 2023 07 05.
Article
em En
| MEDLINE
| ID: mdl-37310262
Tumor-specific drug-delivering nanocarriers could be a promising modality for next-generation tumor therapy. Here we developed a Burkitt lymphoma-specific DNA aptamer-labeled nanocarrier using the ß-Annulus peptide, which forms a spherical nanoassembly called artificial viral capsid. Dynamic light scattering and transmission electron microscopy of the DNA aptamer-decorated artificial viral capsid showed the formation of spherical assemblies with a diameter of approximately 50-150 nm. The artificial viral capsid was selectively internalized into the Burkitt lymphoma cell line, Daudi, and doxorubicin complexed with the capsid selectively killed Daudi cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfoma de Burkitt
/
Aptâmeros de Nucleotídeos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article