EZH2 Expression in Retinoblastoma: A Potential Therapeutic Target.
Ophthalmic Res
; 66(1): 1014-1019, 2023.
Article
em En
| MEDLINE
| ID: mdl-37311441
ABSTRACT
INTRODUCTION:
The enhancer of zeste homolog 2 (EZH2) is a member of the polycomb repressive complex 2 (PRC2) and is important in cell-cycle regulation. Increased expression of EZH2 has been reported in retinoblastoma (RB). The aim of the study was to determine EZH2 expression, compare this with clinicopathological parameters in RB, and assess its relationship with tumor cell proliferation.METHODS:
Ninety-nine retrospective cases of enucleated RB were included in the present study. Expression of EZH2 and the marker of cell proliferation, Ki67, were investigated by immunohistochemistry.RESULTS:
Among the 99 cases of RB in this study, EZH2 was found highly expressed (positive expression rate ≥70%) in 92 cases. EZH2 was expressed in tumor cells but absent in normal retinal tissues. The expression of EZH2 was positively linked to Ki67 expression (r = 0.65, p < 0.001).CONCLUSION:
Elevated EZH2 expression was found in most RB cases, indicating that EZH2 could be a potential therapeutic target for RB.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Retinoblastoma
/
Neoplasias da Retina
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article