Bicyclic Amidine-Triggered Cyclization of o-Alkynylisocyanobenzenes: Synthesis of Lactam-Derived Quinolines.
J Org Chem
; 88(13): 8379-8386, 2023 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-37312277
ABSTRACT
Efficient access to the synthesis of lactam-derived quinoline through a bicyclic amidine-triggered cyclization reaction from readily prepared o-alkynylisocyanobenzenes has been developed. The reaction was initiated by nucleophilic attack of the bicyclic amidines to o-alkynylisocyanobenzenes, subsequently with intramolecular cyclization to produce a DBU-quinoline-based amidinium salt, followed by hydrolysis to afford the lactam-derived quinoline in moderate to good yields.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Lactamas
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article