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Basic Mechanisms of Hemolysis-Associated Thrombo-Inflammation and Immune Dysregulation.
Dimitrov, Jordan D; Roumenina, Lubka T; Perrella, Gina; Rayes, Julie.
Afiliação
  • Dimitrov JD; Centre de Recherche des Cordeliers, INSERM, CNRS, Sorbonne Université, Université de Paris, Centre de Recherche des Cordeliers, France (J.D.D., L.T.R.).
  • Roumenina LT; Centre de Recherche des Cordeliers, INSERM, CNRS, Sorbonne Université, Université de Paris, Centre de Recherche des Cordeliers, France (J.D.D., L.T.R.).
  • Perrella G; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (G.P., J.R.).
  • Rayes J; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (G.P., J.R.).
Arterioscler Thromb Vasc Biol ; 43(8): 1349-1361, 2023 08.
Article em En | MEDLINE | ID: mdl-37317847
Independent of etiology, hemolytic diseases are associated with thrombosis, inflammation and immune dysregulation, all together contributing to organ damage and poor outcome. Beyond anemia and the loss of the anti-inflammatory functions of red blood cells, hemolysis leads to the release of damage-associated molecular patterns including ADP, hemoglobin, and heme, which act through multiple receptors and signaling pathways fostering a hyperinflammatory and hypercoagulable state. Extracellular free heme is promiscuous alarmin capable of triggering oxido-inflammatory and thrombotic events by inducing the activation of platelets, endothelial and innate cells as well as the coagulation and complement cascades. In this review, we discuss the main mechanisms by which hemolysis and, in particular, heme, drive this thrombo-inflammatory milieu and discuss the consequences of hemolysis on the host response to secondary infections.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemoglobinas / Hemólise Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemoglobinas / Hemólise Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article