Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells.

Nishikubo, Kou; Ohgaki, Ryuichi; Liu, Xingming; Okanishi, Hiroki; Xu, Minhui; Endou, Hitoshi; Kanai, Yoshikatsu

Nishikubo, Kou; Ohgaki, Ryuichi; Liu, Xingming; Okanishi, Hiroki; Xu, Minhui; Endou, Hitoshi; Kanai, Yoshikatsu.

Afiliação

Nishikubo K; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Ohgaki R; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. ohgaki@pharma1.med.osaka-u.ac.jp.
Liu X; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Osaka, Japan. ohgaki@pharma1.med.osaka-u.ac.jp.
Okanishi H; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Xu M; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Endou H; Department of Bio-system Pharmacology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kanai Y; J-Pharma Co., Ltd., Yokohama, Japan.

Cancer Cell Int ; 23(1): 116, 2023 Jun 15.

Article em En | MEDLINE | ID: mdl-37322479

Palavras-chave

Amino acid transporter; Cancer chemotherapy; Combination therapy; Cytotoxic anticancer drugs; Essential amino acids; Gemcitabine; LAT1; Large neutral amino acids; Molecularly targeted drugs; SLC7A5

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article