Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A.
J Gerontol A Biol Sci Med Sci
; 78(Suppl 1): 44-52, 2023 06 16.
Article
em En
| MEDLINE
| ID: mdl-37325960
ABSTRACT
In recent years, several new classes of therapies have been investigated with their potential for restoring or improving physical functioning in older adults. These have included Mas receptor agonists, regulators of mitophagy, skeletal muscle troponin activators, anti-inflammatory compounds, and targets of orphan nuclear receptors. The present article summarizes recent developments of the function-promoting effects of these exciting new compounds and shares relevant preclinical and clinical data related to their safety and efficacy. The development of novel compounds in this area is expanding and likely will need the advent of a new treatment paradigm for age-associated mobility loss and disability.
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Base de dados:
MEDLINE
Assunto principal:
Receptores Nucleares Órfãos
/
Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article