Alveolar macrophages from EVALI patients and e-cigarette users: a story of shifting phenotype.
Respir Res
; 24(1): 162, 2023 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-37330506
ABSTRACT
Exposure to e-cigarette vapors alters important biologic processes including phagocytosis, lipid metabolism, and cytokine activity in the airways and alveolar spaces. Little is known about the biologic mechanisms underpinning the conversion to e-cigarette, or vaping, product use-associated lung injury (EVALI) from normal e-cigarette use in otherwise healthy individuals. We compared cell populations and inflammatory immune populations from bronchoalveolar lavage fluid in individuals with EVALI to e-cigarette users without respiratory disease and healthy controls and found that e-cigarette users with EVALI demonstrate a neutrophilic inflammation with alveolar macrophages skewed towards inflammatory (M1) phenotype and cytokine profile. Comparatively, e-cigarette users without EVALI demonstrate lower inflammatory cytokine production and express features associated with a reparative (M2) phenotype. These data indicate macrophage-specific changes are occurring in e-cigarette users who develop EVALI.
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Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Lesão Pulmonar
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Sistemas Eletrônicos de Liberação de Nicotina
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article