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Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells.
Piccarducci, Rebecca; Giacomelli, Chiara; Bertilacchi, Maria Sofia; Benito-Martinez, Andrea; Di Giorgi, Nicoletta; Daniele, Simona; Signore, Giovanni; Rocchiccioli, Silvia; Vilar, Marçal; Marchetti, Laura; Martini, Claudia.
Afiliação
  • Piccarducci R; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.
  • Giacomelli C; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.
  • Bertilacchi MS; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.
  • Benito-Martinez A; Instituto de Biomedicina de Valencia-CSIC Spanish National Research Council, 46010 Valencia, Spain.
  • Di Giorgi N; Institute of Clinical Physiology-CNR, 56124 Pisa, Italy.
  • Daniele S; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.
  • Signore G; Department of Biology, University of Pisa, 56126 Pisa, Italy.
  • Rocchiccioli S; Institute of Clinical Physiology-CNR, 56124 Pisa, Italy.
  • Vilar M; Instituto de Biomedicina de Valencia-CSIC Spanish National Research Council, 46010 Valencia, Spain.
  • Marchetti L; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy. Electronic address: laura.marchetti@unipi.it.
  • Martini C; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy. Electronic address: claudia.martini@unipi.it.
Biochim Biophys Acta Mol Basis Dis ; 1869(7): 166793, 2023 10.
Article em En | MEDLINE | ID: mdl-37336366
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteína E4 / Doença de Alzheimer Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteína E4 / Doença de Alzheimer Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article