Mild and selective hydrogen-deuterium exchange for aromatic hydrogen of amines.
J Labelled Comp Radiopharm
; 66(10): 321-331, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-37337654
ABSTRACT
The direct electrophilic deuteration of the aromatic moiety in aromatic and aralkyl amines is reported. The acid-catalyzed deuteration is facilitated by deuterated trifluoromethanesulfonic acid, [D]triflic acid, CF3 SO3 D, TfOD, which acts as both the reaction solvent and the source of the deuterium label. The mild conditions enable room temperature hydrogen/deuterium exchange for most of the para-substituted aromatic amine derivatives studied. In addition, short reaction times and a high degree of aromatic deuteration are achieved and isolation of the product is simple. The optical activity of the chiral aralkyl amines studied was preserved.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Aminas
/
Hidrogênio
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article