Injectable Ventral Spinal Stimulator Evokes Programmable and Biomimetic Hindlimb Motion.
Nano Lett
; 23(13): 6184-6192, 2023 07 12.
Article
em En
| MEDLINE
| ID: mdl-37338198
ABSTRACT
Spinal cord neuromodulation can restore partial to complete loss of motor functions associated with neuromotor disease and trauma. Current technologies have made substantial progress but have limitations as dorsal epidural or intraspinal devices that are either remote to ventral motor neurons or subject to surgical intervention in the spinal tissue. Here, we describe a flexible and stretchable spinal stimulator design with nanoscale thickness that can be implanted by minimally invasive injection through a polymeric catheter to target the ventral spinal space of mice. Ventrolaterally implanted devices exhibited substantially lower stimulation threshold currents and more precise recruitment of motor pools than did comparable dorsal epidural implants. Functionally relevant and novel hindlimb movements were achieved via specific stimulation patterns of the electrodes. This approach holds translational potential for improving controllable limb function following spinal cord injury or neuromotor disease.
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Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
/
Biomimética
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article