Design, Synthesis and Evaluation of Fluorescent Properties of Benzothiazole Derivatives.
Chemphyschem
; 24(17): e202300159, 2023 09 01.
Article
em En
| MEDLINE
| ID: mdl-37349282
ABSTRACT
Fluorescence imaging is conducive to establish a bridge between molecular biology and clinical medicine, and provides new tools for disease process research, early diagnosis, and efficacy evaluation, because of the advantages of rapid imaging and nondestructive detection. Herein, a series of fluorescent molecules with thiadiazole, or thiazole, or benzothiazole cores were designed and synthesized to develop more excellent fluorescent molecules in bio-imaging. According to theoretical and experimental methods, we found that benzothiazole derivative 14 B with conjugate expansion by (4-aminophenyl) ethynyl group was the most excellent fluorescent molecule among all the investigated compounds and exhibited low cytotoxicity and strong blue and green fluorescence by confocal cell imaging.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tiadiazóis
/
Benzotiazóis
Tipo de estudo:
Screening_studies
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article