Recent research advances in ATX inhibitors: An overview of primary literature.
Bioorg Med Chem
; 90: 117374, 2023 07 15.
Article
em En
| MEDLINE
| ID: mdl-37354726
ABSTRACT
The autoglobulin gene is the main enzyme for circulating LPA production and has lysophosphatidylcholine D activity, which catalyzes the production of lysophosphatidic acid and choline with lysophosphatidylcholine as substrate. A growing body of experimental evidence suggests that autoglobulin is involved in the pathogenesis of a variety of diseases. This review summarizes the different structural ATX inhibitors classified according to their binding mode to the ATX triple orientation site, and summarizes the conformational relationships and molecular docking of each type with ATX structure, hoping to contribute to the development of novel ATX inhibitors.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lisofosfatidilcolinas
/
Diester Fosfórico Hidrolases
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article