Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/ß-catenin signaling pathway.

Yoon, Minguen; Kim, Heejene; Shin, Heewon; Lee, HeeYang; Kang, Min-Jeong; Park, Sung-Hye; Han, Gyoonhee; Kim, YoungSoo; Choi, Kang-Yell

Yoon, Minguen; Kim, Heejene; Shin, Heewon; Lee, HeeYang; Kang, Min-Jeong; Park, Sung-Hye; Han, Gyoonhee; Kim, YoungSoo; Choi, Kang-Yell.

Afiliação

Yoon M; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
Kim H; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
Shin H; Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.
Lee H; Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.
Kang MJ; CK Regeon Inc, Seoul 03722, Republic of Korea.
Park SH; Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Han G; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
Kim Y; Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea. Electronic address: y.kim@yonsei.ac.kr.
Choi KY; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea; CK Regeon Inc, Seoul 03722, Republic of Korea. Electronic address: kychoi@ckregeon.com.

Pharmacol Res ; 194: 106836, 2023 08.

Article em En | MEDLINE | ID: mdl-37355147

Assuntos

Doença de Alzheimer; Via de Sinalização Wnt; Animais; Camundongos; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; beta Catenina/metabolismo; Modelos Animais de Doenças; Proteínas de Ligação a DNA/metabolismo; Camundongos Transgênicos; Fatores de Transcrição; Humanos

Palavras-chave

5xFAD; Alzheimer's disease; CXXC5; CXXC5-Dvl protein-protein interaction; Cxxc5(-/-)/5xFAD mice; Wnt/ß-catenin signaling pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Via de Sinalização Wnt Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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