APP-BACE1 Interaction and Intracellular Localization Regulate Aß Production in iPSC-Derived Cortical Neurons.

Roselli, Sandra; Satir, Tugce Munise; Camacho, Rafael; Fruhwürth, Stefanie; Bergström, Petra; Zetterberg, Henrik; Agholme, Lotta

Roselli, Sandra; Satir, Tugce Munise; Camacho, Rafael; Fruhwürth, Stefanie; Bergström, Petra; Zetterberg, Henrik; Agholme, Lotta.

Afiliação

Roselli S; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Blå Stråket 15, Sahlgrenska Hospital, 405 30, Gothenburg, Sweden. sandra.roselli@gu.se.
Satir TM; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Blå Stråket 15, Sahlgrenska Hospital, 405 30, Gothenburg, Sweden.
Camacho R; Centre for Cellular Imaging, Core Facilities, The Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 7A, 405 30, Gothenburg, Sweden.
Fruhwürth S; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Blå Stråket 15, Sahlgrenska Hospital, 405 30, Gothenburg, Sweden.
Bergström P; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Blå Stråket 15, Sahlgrenska Hospital, 405 30, Gothenburg, Sweden.
Zetterberg H; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Blå Stråket 15, Sahlgrenska Hospital, 405 30, Gothenburg, Sweden.
Agholme L; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Building V3, Mölndal Hospital, 431 80, Mölndal, Sweden.

Cell Mol Neurobiol ; 43(7): 3653-3668, 2023 Oct.

Article em En | MEDLINE | ID: mdl-37355492

Assuntos

Doença de Alzheimer; Células-Tronco Pluripotentes Induzidas; Humanos; Precursor de Proteína beta-Amiloide; Peptídeos beta-Amiloides; Secretases da Proteína Precursora do Amiloide; Ácido Aspártico Endopeptidases; Neurônios

Palavras-chave

Amyloid beta; Amyloid precursor protein; Beta secretase; Early endosomes; Gamma secretase; Neurons; Proximity ligation assay

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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