cCMP and cUMP phosphodiesterases in viral infections.
Trends Biochem Sci
; 48(10): 835-838, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37365086
ABSTRACT
In bacteria, cCMP and cUMP have a key role in defense against infection with bacterial viruses. Bacteriophages encode phosphodiesterases (PDEs; 'nucleases'; Apyc1), which cleave cCMP/cUMP, counteracting this defense. We propose that PDEs are of broader biological relevance, including cCMP/cUMP-cleaving PDEs of eukaryotic viruses, which may constitute new drug targets.
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Base de dados:
MEDLINE
Assunto principal:
Viroses
/
Diester Fosfórico Hidrolases
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article