Feasibility and safety of introducing cashew nut spread in infant diets-A randomized trial.
Pediatr Allergy Immunol
; 34(6): e13969, 2023 06.
Article
em En
| MEDLINE
| ID: mdl-37366200
ABSTRACT
BACKGROUND:
To reduce peanut allergy prevalence, infant feeding guidelines now recommend introducing peanuts in an age-appropriate form (such as peanut butter) as part of complementary feeding. However, due to a lack of randomized trial evidence, most infant feeding and food allergy prevention guidelines do not include tree nuts. The aims of this trial were to determine safety and feasibility of dosage consumption recommendations for infant cashew nut spread introduction.METHODS:
This is a parallel, three-arm (111 allocation), single-blinded (outcome assessors), randomized controlled trial. General population term infants were randomized at 6-8 months of age to either a one teaspoon (Intervention 1 n = 59) or increasing dosage regime of one teaspoon at 6-7 months, two teaspoons at 8-9 months, and three teaspoons from 10 months of age onwards (Intervention 2 n = 67) cashew nut spread, both three times per week, or no specific advice on cashew introduction (Control n = 70). At 1 year of age, food challenge proven IgE-mediated cashew nut allergy was assessed.RESULTS:
Compliance in Intervention 1 (92%) was higher than Intervention 2 (79%), p = .04. Only one infant had delayed (at 5 h) facial swelling and eczema flare to cashew introduction at 6.5 months, but no cashew allergy at 1 year. Only one infant (Control) had cashew allergy at 1 year, and this infant had not been introduced to cashew prior to 12 months of age.CONCLUSION:
Regular infant consumption of one teaspoon of cashew nut spread three times per week from 6 to 8 months of age was found to be feasible and safe.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipersensibilidade a Noz
/
Hipersensibilidade a Amendoim
/
Anacardium
/
Hipersensibilidade Alimentar
Tipo de estudo:
Clinical_trials
/
Risk_factors_studies
Limite:
Humans
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Infant
/
Newborn
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article