Your browser doesn't support javascript.
loading
The NLRP3 inflammasome: contributions to inflammation-related diseases.
Chen, Ying; Ye, Xingyan; Escames, Germaine; Lei, Wangrui; Zhang, Xin; Li, Meng; Jing, Tong; Yao, Yu; Qiu, Zhenye; Wang, Zheng; Acuña-Castroviejo, Darío; Yang, Yang.
Afiliação
  • Chen Y; Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Ye X; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
  • Escames G; Department of Neurology, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, China.
  • Lei W; Biomedical Research Center, Health Sciences Technology Park, University of Granada, Avda. del Conocimiento s/n, Granada, Spain.
  • Zhang X; Ibs. Granada and CIBERfes, Granada, Spain.
  • Li M; UGC of Clinical Laboratories, University San Cecilio's Hospital, Granada, Spain.
  • Jing T; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
  • Yao Y; Department of Neurology, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, China.
  • Qiu Z; Department of Cardiology, Affiliated Hospital, Yan'an University, Yan'an, China.
  • Wang Z; Department of Cardiology, Affiliated Hospital, Yan'an University, Yan'an, China.
  • Acuña-Castroviejo D; Department of Cardiology, Affiliated Hospital, Yan'an University, Yan'an, China.
  • Yang Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
Cell Mol Biol Lett ; 28(1): 51, 2023 Jun 27.
Article em En | MEDLINE | ID: mdl-37370025
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1ß and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including arthritis, Alzheimer's disease, inflammatory bowel disease, and other autoimmune and autoinflammatory diseases. This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the NLRP3 inflammasome to treat inflammation-related diseases, and provide new ideas for clinical treatment.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article