Cancer stem cell fate determination: mito-nuclear communication.
Cell Commun Signal
; 21(1): 159, 2023 06 27.
Article
em En
| MEDLINE
| ID: mdl-37370081
ABSTRACT
Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and metastasis. Therefore, clarification of the mechanisms involved in CSC stemness maintenance and cell fate determination would provide a new strategy for cancer therapy. Unregulated cellular energetics has been accepted as one of the hallmarks of cancer cells, but recent studies have revealed that mitochondrial metabolism can also actively determine CSC fate by affecting nuclear stemness gene expression. Herein, from the perspective of mito-nuclear communication, we review recent progress on the influence of mitochondria on CSC potential from four aspects metabolism, dynamics, mitochondrial homeostasis, and reactive oxygen species (ROS). Video Abstract.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mitomicina
/
Recidiva Local de Neoplasia
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article