Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress.

Tan, Winston J T; Santos-Sacchi, Joseph; Tonello, Jane; Shanker, Anil; Ivanova, Alla V

Tan, Winston J T; Santos-Sacchi, Joseph; Tonello, Jane; Shanker, Anil; Ivanova, Alla V.

Afiliação

Tan WJT; Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand.
Santos-Sacchi J; Department of Surgery (Otolaryngology), Yale University School of Medicine, New Haven, CT 06510, USA.
Tonello J; Department of Surgery (Otolaryngology), Yale University School of Medicine, New Haven, CT 06510, USA.
Shanker A; School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
Ivanova AV; School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.

Antioxidants (Basel) ; 12(6)2023 Jun 06.

Article em En | MEDLINE | ID: mdl-37371955

Palavras-chave

2-DG; 2-deoxy-D-glucose; Fus1/Tusc2; Seahorse analysis; age-related hearing loss; cochlea; mitochondria; mitochondrial dysfunction; oxidative stress; rapamycin

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article