Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson's Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment.

Atiq, Abubakar; Lee, Hyeon Jin; Khan, Amjad; Kang, Min Hwa; Rehman, Inayat Ur; Ahmad, Riaz; Tahir, Muhammad; Ali, Jawad; Choe, Kyonghwan; Park, Jun Sung; Kim, Myeong Ok

Atiq, Abubakar; Lee, Hyeon Jin; Khan, Amjad; Kang, Min Hwa; Rehman, Inayat Ur; Ahmad, Riaz; Tahir, Muhammad; Ali, Jawad; Choe, Kyonghwan; Park, Jun Sung; Kim, Myeong Ok.

Afiliação

Atiq A; Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Lee HJ; Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Khan A; Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Kang MH; Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Rehman IU; Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Ahmad R; Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Tahir M; Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Ali J; Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Choe K; Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Park JS; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6229 ER Maastricht, The Netherlands.
Kim MO; Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.

Int J Mol Sci ; 24(12)2023 Jun 09.

Article em En | MEDLINE | ID: mdl-37373089

Assuntos

Transtornos Motores; Fármacos Neuroprotetores; Doença de Parkinson; Animais; Camundongos; Doença de Parkinson/tratamento farmacológico; Doença de Parkinson/etiologia; Doença de Parkinson/metabolismo; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina/efeitos adversos; Doenças Neuroinflamatórias; Vitamina E/farmacologia; Transtornos Motores/metabolismo; Substância Negra/metabolismo; Camundongos Endogâmicos C57BL; Tirosina 3-Mono-Oxigenase/metabolismo; Neurônios Dopaminérgicos/metabolismo; Fármacos Neuroprotetores/farmacologia; Fármacos Neuroprotetores/uso terapêutico; Fármacos Neuroprotetores/metabolismo; Estresse Oxidativo; Modelos Animais de Doenças

Palavras-chave

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); neurodegeneration; neuroinflammation; oxidative stress; substantia nigra pars compacta (SNpc); trolox

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Fármacos Neuroprotetores / Transtornos Motores Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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